Publications – Page 2

A TGFβ-miR-182-BRCA1 axis controls the mammary differentiation hierarchy.

Haydeliz Martinez-Ruiz, Irineu Illa-Bochaca, Coral Omene, Douglas Hanniford, Qi Liu, Eva Hernando, Mary Helen Barcellos-Hoff

Sci Signal.

2016 Dec 6;

(457):

ra118.

doi: 10.1126/scisignal.aaf5402.

Epub 2016 Dec 6.

Dec 6, 2016

SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150.

A Barbáchano, A Fernández-Barral, F Pereira, M F Segura, P Ordóñez-Morán, E Carrillo-de Santa Pau, J M González-Sancho, D Hanniford, N Martínez, A Costales-Carrera, F X Real, H G Pálmer, J M Rojas, E Hernando, A Muñoz

Oncogene.

2016 Jun 9;

(23):

2991-3003.

doi: 10.1038/onc.2015.366.

Epub 2015 Oct 12.

Jun 9, 2016

BET and BRAF inhibitors act synergistically against BRAF-mutant melanoma.

Luca Paoluzzi, Douglas Hanniford, Elena Sokolova, Iman Osman, Farbod Darvishian, Jinhua Wang, James E Bradner, Eva Hernando

Cancer Med.

2016 Jun;

(6):

1183-93.

doi: 10.1002/cam4.667.

Epub 2016 May 11.

Jun 1, 2016

A miRNA-Based Signature Detected in Primary Melanoma Tissue Predicts Development of Brain Metastasis.

Doug Hanniford, Judy Zhong, Lisa Koetz, Avital Gaziel-Sovran, Daniel J Lackaye, Shulian Shang, Anna Pavlick, Richard Shapiro, Russell Berman, Farbod Darvishian, Yongzhao Shao, Iman Osman, Eva Hernando

Clin Cancer Res.

2015 Nov 1;

(21):

4903-12.

doi: 10.1158/1078-0432.CCR-14-2566.

Epub 2015 Jun 18.

Nov 1, 2015

Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma.

Chiara Vardabasso, Alexandre Gaspar-Maia, Dan Hasson, Sebastian Pünzeler, David Valle-Garcia, Tobias Straub, Eva C Keilhauer, Thomas Strub, Joanna Dong, Taniya Panda, Chi-Yeh Chung, Jonathan L Yao, Rajendra Singh, Miguel F Segura, Barbara Fontanals-Cirera, Amit Verma, Matthias Mann, Eva Hernando, Sandra B Hake, Emily Bernstein

Mol Cell.

2015 Jul 2;

(1):

75-88.

doi: 10.1016/j.molcel.2015.05.009.

Epub 2015 Jun 4.

Jul 2, 2015

The Mammalian Cell Cycle Regulates Parvovirus Nuclear Capsid Assembly.

Jon Gil-Ranedo, Eva Hernando, Laura Riolobos, Carlos Domínguez, Michael Kann, José M Almendral

PLoS Pathog.

2015 Jun;

(6):

e1004920.

doi: 10.1371/journal.ppat.1004920.

Epub 2015 Jun 11.

Jun 1, 2015

FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification.

Nikos Kourtis, Rana S Moubarak, Beatriz Aranda-Orgilles, Kevin Lui, Iraz T Aydin, Thomas Trimarchi, Farbod Darvishian, Christine Salvaggio, Judy Zhong, Kamala Bhatt, Emily I Chen, Julide T Celebi, Charalampos Lazaris, Aristotelis Tsirigos, Iman Osman, Eva Hernando, Iannis Aifantis

Nat Cell Biol.

2015 Mar;

(3):

322-332.

doi: 10.1038/ncb3121.

Mar 1, 2015

Identification of metastasis-suppressive microRNAs in primary melanoma.

Doug Hanniford, Miguel F Segura, Judy Zhong, Elliot Philips, Xavier Jirau-Serrano, Farbod Darvishian, Russell S Berman, Richard L Shapiro, Anna C Pavlick, Brian Brown, Iman Osman, Eva Hernando

J Natl Cancer Inst.

2015 Mar;

107

(3):

doi: 10.1093/jnci/dju494.

Epub 2015 Feb 12.

Mar 1, 2015

Limited miR-17-92 overexpression drives hematologic malignancies.

Laura S Danielson, Linsey Reavie, Marc Coussens, Veronica Davalos, Mireia Castillo-Martin, Maria V Guijarro, Maryaline Coffre, Carlos Cordon-Cardo, Iannis Aifantis, Sherif Ibrahim, Cynthia Liu, Sergei B Koralov, Eva Hernando

Leuk Res.

2015 Mar;

(3):

335-41.

doi: 10.1016/j.leukres.2014.12.002.

Epub 2014 Dec 10.

Mar 1, 2015

Serum-based miRNAs in the prediction and detection of recurrence in melanoma patients.

Nathaniel H Fleming, Judy Zhong, Inês Pires da Silva, Eleazar Vega-Saenz de Miera, Bobbi Brady, Sung Won Han, Doug Hanniford, Jinhua Wang, Richard L Shapiro, Eva Hernando, Iman Osman

Cancer.

2015 Jan 1;

121

(1):

51-9.

doi: 10.1002/cncr.28981.

Epub 2014 Aug 25.

Jan 1, 2015

Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes.

Raffaella Di Micco, Barbara Fontanals-Cirera, Vivien Low, Panagiotis Ntziachristos, Stephanie K Yuen, Claudia D Lovell, Igor Dolgalev, Yoshiya Yonekubo, Guangtao Zhang, Elena Rusinova, Guillermo Gerona-Navarro, Marta Cañamero, Michael Ohlmeyer, Iannis Aifantis, Ming-Ming Zhou, Aristotelis Tsirigos, Eva Hernando

Cell Rep.

2014 Oct 9;

(1):

234-247.

doi: 10.1016/j.celrep.2014.08.055.

Epub 2014 Sep 26.

Oct 9, 2014

Anti-miR182 reduces ovarian cancer burden, invasion, and metastasis: an in vivo study in orthotopic xenografts of nude mice.

Xiaofei Xu, Bushra Ayub, Zhaojian Liu, Vanida Ann Serna, Wenan Qiang, Yugang Liu, Eva Hernando, Sonya Zabludoff, Takeshi Kurita, Beihua Kong, Jian-Jun Wei

Mol Cancer Ther.

2014 Jul;

(7):

1729-39.

doi: 10.1158/1535-7163.MCT-13-0982.

Epub 2014 May 13.

Jul 1, 2014

Clinicopathological characteristics at primary melanoma diagnosis as risk factors for brain metastasis.

Meng Qian, Michelle W Ma, Nathaniel H Fleming, Daniel J Lackaye, Eva Hernando, Iman Osman, Yongzhao Shao

Melanoma Res.

2013 Dec;

(6):

461-7.

doi: 10.1097/CMR.0000000000000015.

Dec 1, 2013

Hedgehog pathway blockade inhibits melanoma cell growth in vitro and in vivo.

Kathryn E O'Reilly, Eleazar Vega-Saenz de Miera, Miguel F Segura, Erica Friedman, Laura Poliseno, Sung Won Han, Judy Zhong, Jiri Zavadil, Anna Pavlick, Eva Hernando, Iman Osman

Pharmaceuticals (Basel).

2013 Nov 11;

(11):

1429-50.

doi: 10.3390/ph6111429.

Epub 2013 Nov 11.

Nov 11, 2013

BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy.

Miguel F Segura, Bárbara Fontanals-Cirera, Avital Gaziel-Sovran, María V Guijarro, Doug Hanniford, Guangtao Zhang, Pilar González-Gomez, Marta Morante, Luz Jubierre, Weijia Zhang, Farbod Darvishian, Michael Ohlmeyer, Iman Osman, Ming-Ming Zhou, Eva Hernando

Cancer Res.

2013 Oct 15;

(20):

6264-76.

doi: 10.1158/0008-5472.CAN-13-0122-T.

Epub 2013 Aug 15.

Oct 15, 2013

Development and characterization of a clinically relevant mouse model of melanoma brain metastasis.

Amr Morsi, Avital Gaziel-Sovran, William Cruz-Munoz, Robert S Kerbel, John G Golfinos, Eva Hernando, Youssef Z Wadghiri

Pigment Cell Melanoma Res.

2013 Sep;

(5):

743-5.

doi: 10.1111/pcmr.12114.

Epub 2013 Jun 4.

Sep 1, 2013

Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling.

Maria V Guijarro, Sonika Dahiya, Laura S Danielson, Miguel F Segura, Frances M Vales-Lara, Silvia Menendez, Dorota Popiolek, Khushbakhat Mittal, Jian Jun Wei, Jiri Zavadil, Carlos Cordon-Cardo, Pier Paolo Pandolfi, Eva Hernando

Am J Pathol.

2013 Jun;

182

(6):

2015-27.

doi: 10.1016/j.ajpath.2013.02.035.

Jun 1, 2013

FBH1 protects melanocytes from transformation and is deregulated in melanomas.

Yeon-Tae Jeong, Lukas Cermak, Maria V Guijarro, Eva Hernando, Michele Pagano

Cell Cycle.

2013 Apr 1;

(7):

1128-32.

doi: 10.4161/cc.24165.

Epub 2013 Mar 6.

Apr 1, 2013

Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis.

Laura S Danielson, David S Park, Noemi Rotllan, Aranzazu Chamorro-Jorganes, Maria V Guijarro, Carlos Fernandez-Hernando, Glenn I Fishman, Colin K L Phoon, Eva Hernando

FASEB J.

2013 Apr;

(4):

1460-7.

doi: 10.1096/fj.12-221994.

Epub 2012 Dec 27.

Apr 1, 2013

Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit.

Penelope Pelczar, Arne Zibat, Willemijn A van Dop, Jarom Heijmans, Annalen Bleckmann, Wolfgang Gruber, Frauke Nitzki, Anja Uhmann, Maria V Guijarro, Eva Hernando, Kai Dittmann, Jürgen Wienands, Ralf Dressel, Leszek Wojnowski, Claudia Binder, Takahiro Taguchi, Tim Beissbarth, Pancras C W Hogendoorn, Cristina R Antonescu, Brian P Rubin, Walter Schulz-Schaeffer, Fritz Aberger, Gijs R van den Brink, Heidi Hahn

Gastroenterology.

2013 Jan;

144

(1):

134-144.e6.

doi: 10.1053/j.gastro.2012.09.061.

Epub 2012 Oct 3.

Jan 1, 2013

MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma.

Zhaojian Liu, Jinsong Liu, Miguel F Segura, Changshun Shao, Peng Lee, Yaoqin Gong, Eva Hernando, Jian-Jun Wei

J Pathol.

2012 Oct;

228

(2):

204-15.

doi: 10.1002/path.4000.

Epub 2012 Apr 18.

Oct 1, 2012

Serum microRNAs as biomarkers for recurrence in melanoma.

Erica B Friedman, Shulian Shang, Eleazar Vega-Saenz de Miera, Jacob Ulrik Fog, Maria Wrang Teilum, Michelle W Ma, Russell S Berman, Richard L Shapiro, Anna C Pavlick, Eva Hernando, Adam Baker, Yongzhao Shao, Iman Osman

J Transl Med.

2012 Aug 2;

155.

doi: 10.1186/1479-5876-10-155.

Epub 2012 Aug 2.

Aug 2, 2012

Challenging the current paradigm of melanoma progression: brain metastasis as isolated first visceral site.

Michelle W Ma, Meng Qian, Daniel J Lackaye, Russell S Berman, Richard L Shapiro, Anna C Pavlick, John G Golfinos, Erik C Parker, Farbod Darvishian, Eva Hernando, Yongzhao Shao, Iman Osman

Neuro Oncol.

2012 Jul;

(7):

849-58.

doi: 10.1093/neuonc/nos113.

Epub 2012 May 3.

Jul 1, 2012

Histology-specific microRNA alterations in melanoma.

Laura Poliseno, Adele Haimovic, Miguel F Segura, Douglas Hanniford, Paul J Christos, Farbod Darvishian, Jinhua Wang, Richard L Shapiro, Anna C Pavlick, Russell S Berman, Eva Hernando, Jiri Zavadil, Iman Osman

J Invest Dermatol.

2012 Jul;

132

(7):

1860-8.

doi: 10.1038/jid.2011.451.

Epub 2012 May 3.

Jul 1, 2012

MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells.

Silvia Alvarez-Díaz, Noelia Valle, Gemma Ferrer-Mayorga, Luis Lombardía, Mercedes Herrera, Orlando Domínguez, Miguel F Segura, Félix Bonilla, Eva Hernando, Alberto Muñoz

Hum Mol Genet.

2012 May 15;

(10):

2157-65.

doi: 10.1093/hmg/dds031.

Epub 2012 Feb 10.

May 15, 2012

The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma.

Chanh Huynh, Laura Poliseno, Miguel F Segura, Ratna Medicherla, Adele Haimovic, Silvia Menendez, Shulian Shang, Anna Pavlick, Yongzhao Shao, Farbod Darvishian, John F Boylan, Iman Osman, Eva Hernando

PLoS One.

2011;

(9):

e25264.

doi: 10.1371/journal.pone.0025264.

Epub 2011 Sep 29.

Jul 12, 2011

miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis.

Avital Gaziel-Sovran, Miguel F Segura, Raffaella Di Micco, Mary K Collins, Douglas Hanniford, Eleazar Vega-Saenz de Miera, John F Rakus, John F Dankert, Shulian Shang, Robert S Kerbel, Nina Bhardwaj, Yongzhao Shao, Farbod Darvishian, Jiri Zavadil, Adrian Erlebacher, Lara K Mahal, Iman Osman, Eva Hernando

Cancer Cell.

2011 Jul 12;

(1):

104-18.

doi: 10.1016/j.ccr.2011.05.027.

Jul 12, 2011

Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.

Amy E Rose, Laura Poliseno, Jinhua Wang, Michael Clark, Alexander Pearlman, Guimin Wang, Eleazar C Vega Y Saenz de Miera, Ratna Medicherla, Paul J Christos, Richard Shapiro, Anna Pavlick, Farbod Darvishian, Jiri Zavadil, David Polsky, Eva Hernando, Harry Ostrer, Iman Osman

Cancer Res.

2011 Apr 1;

(7):

2561-71.

doi: 10.1158/0008-5472.CAN-10-2958.

Epub 2011 Feb 22.

Apr 1, 2011

Efficient in vivo microRNA targeting of liver metastasis.

C Huynh, M F Segura, A Gaziel-Sovran, S Menendez, F Darvishian, L Chiriboga, B Levin, D Meruelo, I Osman, J Zavadil, E G Marcusson, E Hernando

Oncogene.

2011 Mar 24;

(12):

1481-8.

doi: 10.1038/onc.2010.523.

Epub 2010 Nov 22.

Mar 24, 2011

Regulation of HMGA1 expression by microRNA-296 affects prostate cancer growth and invasion.

Jian-Jun Wei, Xinyu Wu, Yi Peng, Guizhi Shi, Olca Basturk, Ximing Yang, Garrett Daniels, Iman Osman, Jiangyong Ouyang, Eva Hernando, Angel Pellicer, Johng S Rhim, Jonathan Melamed, Peng Lee

Clin Cancer Res.

2011 Mar 15;

(6):

1297-305.

doi: 10.1158/1078-0432.CCR-10-0993.

Epub 2010 Dec 7.

Mar 15, 2011